Prof. Kobi (Jacob) George

E. ACADEMIC AND PROFESSIONAL AWARDS

(prizes, fellowships, grants, scholarships, etc., list each category separately.)
Prizes
The Kellerman Prize of the Israeli Cardiology Society-1997.
Title: Induction of fatty streak formation in C57BL/6 mice immunized with Mycobacterium tuberculosis.
The Zigler price of the Technion Medical Faculty –1998.
Work title: Differential effects of monoclonal anti-2GPI antibodies on endothelial cells and on the manifestations of experimental APS.
The Yosefa and Leonid Alschwant Prize for research in Medicine in the field of immunology of atherosclerosis. September, 2002
The Prime Minister’s award for Excellence in the name of Itzhak Rabin 2014
Clalit’ Center of Excellence 2014-2016
Clalit’s Center of Excelllence 2018-2019
Medtronic Center of Excellence 2016
Grants
1. 1997 Israel-Slovenia Grant PI: Deleted mutants of human 2-glycoprotein I (Principal Investigator).
2. 2001 Shlezac grant PI: the role of HSP70 in the rat carotid injury model (Principal Investigator).
3. 2001 Chief Scientist PI: The role of T cell costimulatory pathways in atherosclerosis (Principal investigator).
4. 2001 The Vladimir Schreiber Fund PI: The role of tyrphostins AG-126 and AG-556 in the response to injury in murine models (Principal Investigator).
5. 2005 Amgen Academic Research grant PI: the role of erythropoietin in atherogenesis.
6. 2005 Chief Scientist grant PI- The ministry of Health- The involvement of TNF related apoptosis inducing ligand in atherosclerosis. (Principal Investigator).
7. Tel Aviv Sourasky Scientific Excellence grant for outstanding research PI. 25,000$
8. 2006 Gamida-Cell Academic Research grant PI: The role of endothelial progenitors and stem cells in angiogenesis. In vivo and in vitro studies. 80,000$ (Prinicipal Investigator)
9. 2006-The Israeli Science Foundation (ISF) Grant PI. The role of regulatory CD4CD25 Tcells in atherosclerosis. 220,000$ (Prinicipal Investigator).
10. 2006. Colloborative grant of TASMC and Weizmann Institute PI: The role of the Islet-1 gene in transdifferentiation of mesenchymal stem cells to cardiomyocytes. 80,000$
11. 2008-11 FP7 Program Consutruction of nanostructures to attenuate myocardial induced damage. 4,000,000 Euros. PI
12. 2013 Clalit health services grant 20,000 euro, Circulating Endothelal progenitors in patients with aortic stenosis.
13. 2015 Pfizer Grant. The role of regulatory T cells in the pathogenesis of Myocardial Infarction. 25,000 $
14. 2018 Medtoronic Grant. TAVI registry, 10 year follow up of a single center. 20,000$

F. MEMBERSHIP IN PROFESSIONAL SOCIETIES

Year Society Country
1995-2019-Israel Medical Society.
1997-9 New York Academy of Sciences.
2000-2019-Israeli Medical Association-Society for Research, Prevention and Treatment of Atherosclerosis.
2003-2019- The Isreali Society of Cardiology
2004-2019- The European Society of Cardiology
2005-2019 European working group of the study of the pathogenesis of atherosclerosis.
2006-19 Working group of the Israeli Society of Interventional Cardiology.
2005-19 working group on interventional cardiology
of the european society of cardiology (WG10).
2009-19 Working group of the International Society of Heart Research.
G.1. M.D./PhD STUDENTS/PHYSICIANS SUPERVISED BY CANDIDATE
Year Name of student Subject of Thesis Name of Academic Institution
Medical student/MSc Student/MD basic Science rotation (Madei Yesod):
1) Erez Bakshi (Tel Aviv University).1998
Title of MD thesis: Anti-oxidized-low density lipoprotein antibody determination as a predictor of restenosis following percutaneous transluminal coronary angioplasty.
2) Arnon Afek MD. Basic Science Rotation
The effect of immunization with heat shock protein 65 on atherosclerosis in LDL receptor deficient mice. 1999.
3) Efrat Malka. MSc student.
The effect of intravenous gammaglobulins on experimental autoimmune myocarditis in the rat. 2000.
4) Alon Barsheshet. Tel Aviv Univesity student, MD Thesis:
The effect of whole body hyperthermia on the severity of experimental autoimmune myocarditis in the rat, 2001
5) Simon Biner MD. Basic Science Rotation. 2001
The effect of the tyrphostin AG-556 on myocardial infarction in a rat model.
6) Miki Berger MD. Basic Science Rotation. 2001
The effect of Zinc Supplementation on infarct size and myocardial remodelling in a rat model.
7) Sabina Izraelov MD. Basic Science Rotation. 2001
The effect of GPIIb-IIIa inhibitors on lymphocyte activation markers in patients with unstable angina underoging PTCA and stent placement.
8) Esthie Rubinraut. Tel Aviv University student, MD thesis. 2002
The effect of zinc supplementation on intimal hyperplasia in a rat model.
9) Sigal Ben-Shmuel. Tel Aviv University student, MD thesis. 2001
The effect of L-Arginine on lymphocyte activation markers in patients with unstable angina underoging PTCA and stent placement.
10) Jessica Sack Tel Aviv University student, MD thesis. 2002
The effect of the Ras inhibitor Farnesylthiosalycilic acid on intimal hyperplasia in a rat carotid balloon injury model.
11) Arnon Adler MD thesis. Tel Aviv University student, 2001
The expression of Th1/Th2 cytokines in patients with stable versus unstable angina
12) Raffael Rosso MD. Basic science rotation
Serum levels of IL-18 in patients wit stable and unstable angina
13) Tomer Barak. TAU. MD thesis.2003.
The role of antibodies to oxidized LDL in prediction of hospitalization and control in patients with congestive heart failure.
14. Miriam Moraru. MD thesis. 2003.
Autoimmunity to myosin in patients after myocardial infarction.
15. Emil Goldstein. Basic science rotation. 2003.
Expression of active Ras in peripheral mononuclear cells of patients with acute coronary syndromes.
16. Yoav Michowitz MD. Basic science rotation. 2003
Circulating levels of matrix metalloprotases in the sera of patients with coronary ectasia.
17. Haim Shmilovitch. Basic science rotation. 2003-2004
Endothelial progenitor cells in patients with in stent restenosis.
18. Gerald Chen MD Basic Science rotation
Antibodies to troponin I in patients with various forms of cardiomyopathy
19. Lael Werner BSc student, Tel Aviv University
The effect of endothelial progenitor transplantation on myocardial function in dilated cardiomyopathy induced by immunization against cardiac myosin.
20. Shuki Patal MD. Basic science rotation.
Relation of TNF-alpha and IL-6 to NYHA class and ejection fraction in patients with congestive heart failure.
22. Saher Hamed. MSc. Student. The effect of endothelial progenitor cell transfer on cardiotoxicity induced by Adriamycin.
23. Itzhak Bareli MD. Basic Science rotation. Antibodies to Cardiolipid and B2GPI in patients with acute coronary syndromes.
24. Adi Mor MSc. Student. Regulatory T cells in patients with atherosclerotic vascular disease.
25. Jeremy Ben Shoshan. PhD student. The role of HIF-1 alpha in regulation of endothelial stem cells.
26. Victoria shatz MD- Basic Science rotation. Endothelial progenitor cells in patients with rheumatoid arthritis.
27. Natalia Simon MD. Basic Science Rotation. Role of HSP65 in infections and atherogenesis.
28. Irena Shaked BSc student–Predicive value of CRP, NT-PrBNP in patients with clinically controlled heart failure.
30. Karin Mausner- BSC student The effect of HMG co reductase inhibitors on regulatory T cells homeostasis.
31. Sara Wein. Basic Science rotation. Hypoxia inducible factor and functional properties of endothelial cells. University of Melbroure (Third year Medical Student).
32. Sarina Kisil. MD- Basic Science rotation- The role of adiponectin in prediction of heart failure morbidity and mortality.
33. Zacharina Goldstein Basic Science rotation. Endothelial progenitor cells and scleroderman.
34. Aya Barzelay. PhD student (MD/PhD program). The involvement of the islet-1 gene in transdifferentiation of mesenchymal stem cells to cardiomyocytes.
35. Yaacov Shaham MD. Basic Science rotation. The role of thrombopoietin in prediction of coronary events in patients with acute coronary syndromes.
36. Ramit Maoz MD. Basic Science rotation. Antibodies to Annexin II predict clinical outcome in patients with unstable angina.
37. Liora David MD. Basic Science Rotation. Outcome of patients with congestive heart failiure. The role of oxidative stress.
38. Rakefet Pando. MSc Student. Inhibition of experimental myocarditis by the functional Ras inhibitor farnesylthiosalicylin acid (FTS). 2005-2006.
39. Limor Bar. MSc student. The role of coronary suction catheters in prevention of morbidity and mortality in patients with acute MI treated by primary PCI.
40. Yakov Shacham. Basic Science rotation. Anti CRP in patients with acute coronary syndromes.
41. Aya Barzelay. 2007-9. PhD thesis. Tel Aviv University. The role of Isl1 in angiogenesis and transdifferentiation.
42. Jonathan Semo 2008-10. PhD thesis. Tel Aviv University. The role of HIF alpha in myocardial repair.
43. Rinat Sharir PhD. thesis 2009-11. Tel Aviv University. The role of regulatory T cells in ischemia reperfusion damage.
44. Esthie Rubinraut. 2009. Basic Science rotation. Incidence and predictors of heparin induced thrombocytopenia in orthopedic patients.
45. Nissim Giladi PhD thesis. 2009-2011. Mesenchymal stem cells confer immunogenic responses.
46. Diego Medvodovsky. Basic Science Rotation. 2008-9. Phenotypic characterization of PMBC from patients with vulnerable plaques.
47. Tomer Greener. 2008-9. Basic Science rotation. The presence of CCR3 positive lymphocytes in patients with ACS
48. Yossi Ben Shoshan. 2009 MD Thesis. Comparison of predictive power of different EPC phenotypes in prediction of outcome among ACS patients.
49. Yael Ben Haim. Role of tight junctions connexin 43 in cardiomyopathy. 2012
50. Efrat Ron 2009. Basic Science Rotation. The role of HIF gene in differentiation of retinl endothelium.
51. Haberman Dan- Internship rotation. The prevalence of coronary ectasia among patients undergoing coronary catheterizations 2017
52. Heithem Abu Hadiga-Internship rotation. Incidence and outcome of inpatients presenting with myocarditis. 2019

REVIEWER FOR THE FOLLOWING JOURNALS:

1. New England Journal of Medicine
2. Journal of Clinical Investigation
3. Circulation
4. Circulation Research
5. Blood
6. FASEB Journal
7. Journal of The American College of Cardiology
8. Arteriosclerosis Thrombosis and Vascular Biology
9. European Heart Journal
10. Cardiovascular Research
11. Gene Therapy
12. Journal of Mollecular and Cellular Cardiology
13. Atherosclerosis 2001-2005
14. British Journal of Pharmacology
15. Heart
16. Free Radical Research
17. American Journal of Physiology
18. American Journal of Cardiology
19. American Journal of Medicine
20. Thrombosis and Hemostasis
21. International Journal of Cardiology
22. Tissue Engineering
23. IMAJ/Harefuah
24. Annals of Oncology
25. Heart and Vessels
26. Stem Cells
27. American Journal of Hematology
29. Diabetes
30. Lupus Journal
31. Obesity Journal

EDITORIAL BOARD MEMBERSHIP IN THE JOURNALS:

1. THE OPEN TISSUEENGINEERING&REGENERATIVE MEDICINE JOURNAL
2. International Journal of Biological Sciences.
3. The Open Autoimmunity Journal
4. World Journal of Cardiology
5. Journal of Geriatric Cardiology.
6. World Journal of Vaccines
7. World Journal of Translation Medicine
8. Word Journal of Cardiovascular Diseases
9. Current angiogenesis.
10. World Journal of Hypertension

LIST OF PUBLICATIONS

A. BOOKS WRITTEN

1. J. George, Y. Shoenfeld.
Hypertension.
Prolog Press, pp 1-64, 1995
2. J. George, Y. Shoenfeld.
Rheumatic Diseases.
Prolog Press, pp 1-64, 1995.

B.1. ORIGINAL ARTICLES

1. Y. Beigel, J. George, L. Leibovici, A. Mattityahu, S. Sclarovsky, L. Blieden. Coronary risk factors in children of parents with premature coronary heart disease.
Acta Pediatrica 82: 162-165, 1993
2. Y. Levy, J. George, Y. Shoenfeld.
The occurrence of thromboembolic events following airplane flights-’the economy class syndrome’.
Isr J Med Sci 331: 621-23, 1995
3. L. Leibovitch, J. George, Y. Levy, R. Bakimer, Y. Shoenfeld.
Anti actin antibodies determination in sera from patients with autoimmune, liver diseases and patients with carcinomas by ELISA assay.
Immunology Letters 48: 129-132, 1995
4. Y. Levy Y, J. George, M. Hojnik, M. Ehrenfeld, M. Lorber, S. Bombaridieri, Y. Shoenfeld.
Comparison of clinical and laboratory parameters in patients with SLE between Israelis versus Europeans.
Isr J Med Sci 32: 100-104, 1996.
5. G. Zandman-Goddard, J. George, Y. Levy, M. Blank, S. Slavin, Y. Shoenfeld.
Modulation of experimental systemic lupus erythematosus with linomide.
Lupus. 5; 328-333, 1996.
6. G. Zandman-Goddard, J. George, V. Barak, M. Blank, Y. Levy, Y. Shoenfeld.
The effects of early and late administration of M20 IL-1 inhibitor on the manifestations of experimental systemic lupus erythematosus.
Immunology Letters. 53; 77-82, 1996.
7. M. Damianovich, B. Gilburd, J. George, N. Del Papa, A. Afek, I. Goldberg, Y. Kopolovic, D. Roth, G. Barkai, PL Meroni, Y. Shoenfeld.
Pathogenic role of antiendothelial cell antibodies (AECA) in vasculitis: an idiotypic experimental model.
The Journal of Immunology. 156; 4946-4951, 1996.
8. Y. Levy Y, L. Ziporen, B. Gilburd, J. George, S. Polac-Charcon, H. Amital, J. Cledes, P. Youinou, Y. Shoenfeld.
Membraneous nephropathy in primary antiphospholipid syndrome; description of a case and induction of renal injury in SCID mice.
Human Antibodies Hybridomas. 7 91-96, 1996.
9. A. Livneh, JPH. Drenth, IS. Klasen, P. Langevitz, J. George, D. Shelton, DL. Gumucio, E. Pras, DL. Kastner, M. Pras, JWM. van-der Meer.
Familial mediterranean fever and hyperglobulinemia D syndrome: Two diseases with distinct clinical, serological and genetic features.
Journal of Rheumatology. 24; 1558-1563, 1997.
10. J. George, M. Blank, M. Hojnic, E. Bar-Meir, T. Koike, E. Matsuura, M. Lorber, M. Aviram, Y. Shoenfeld.
Oxidized low density lipoprotein (oxLDL) but not LDL aggravates the manifestations of antiphospholipid syndrome (APS).
Clinical and Experimental Immunology. 108; 227-233, 1997.
11. J. George, M. Blank, B. Gilburd, M. Hojnik, B. Shenkman, I. Tamarin, D. Varon, E. Matsuura, T. Koike, Y. Shoenfeld.
Immunologic characterization and functional properties of murine antibodies raised against deleted mutants of human beta 2 glycoprotein I.
International Immunology. 9; 913-921, 1997.
12. J. George, B. Gilburd, Y. Levy, A. Afek, M. Damianovich, A. Doria, S Todesco, Y. Shoenfeld.
“Autoantibody dominance” pattern following idiotypic manipulation of naive mice with different anti-U1RNP antibodies.
Pathobiology. 65; 204-209, 1997.
13. Y. Levy Y, J. George, L. Ziporen, J. Cledes, H. Amital, Y. Bar-dayan, A. Afek, P. Youinou, Y. Shoenfeld.
Massive proteinuria as a main manifestation of primary antiphsopholipid syndrome.
Pathobiology. 66: 49-52, 1998.
14. J. George, A. Afek, B. Gilburd, Y. Levy, M. Blank, J. Kopolovic, D. Harats, Y. Shoenfeld.
Atherosclerosis is accelerated in low-density receptor knockout mice by immunization with anticardiolipin antibodies.
Lupus. 6: 723-729, 1997.
15. J. George, M. Blank, Y. Levy, PL. Meroni, M. Damianovitch, A. Tincani, Y. Shoenfeld.
Differential effects of anti-2 glycoprotein I antibodies on endothelial cells and on the manifestations of experimental antiphospholipid syndrome.
Circulation. 97: 900-906, 1998.
16. M. Blank, J. George, P. Fishman, Y Levy, V Toder, S Savion, Y, Shoenfeld.
Ciprofloxacin immunomodulation of experimental antiphospholipid syndrome associated with elevation of IL-3 and GM-CSF expression.
Arthritis and Rheumatism 41: 224-232, 1998.
17. Y Levy, B Gilburd, J George, M Damianovich, M Blank, N Del-Papa, PL Meroni, P Youinou, Y Shoenfeld.
Monoclonal murine antiendothelial cell antibodies (AECA)-characteristics and binding properties.
International Immunology. 10: 861-868, 1998.
18. M Galleazzi, F Bellisai, GD Sebastiani, G Morozzi, R Marcolongo, F Houssiau, R Cervera, Y Levy, J. George, Y Sherer, Y Shoenfeld.
Association of 16/6 and SA1 anti-DNA idiotypes with anticardiolipin antibodies and clinical manifestations in a large cohort of SLE patients. European Concerted Action on the Immunogenetics of SLE.
Clin Exp Rheumatology. 16: 717-720, 1998.
19. J. George, A. Afek, B. Gilburd, Y. Levy, H. Levkovitz, A Shaish, I. Goldberg, J. Kopolovic, G. Wick, Y. Shoenfeld, D. Harats.
Hyperimmunization of ApoE deficient mice with homologous malondialdehyde low-density lipoprotein suppresses early atherogenesis.
Atherosclerosis. 138: 147-152, 1998.
20. M. Blank, J. George, V. Barak, A. Tincani, T. Koike, Y. Shoenfeld.
Oral tolerance to low dose 2GPI: immunomodulation experimental antiphospholipid syndrome.
The Journal of Immunology. 161: 5303-5312, 1998.
21. J. George, A. Afek, B. Gilburd, Y. Levy, A. Aron-Maor, A. Shaish, H. Levkovitz, M. Blank, D. Harats, Y. Shoenfeld.
Induction of early atherosclerosis in LDL receptor deficient mice by immunization with beta 2 glycoprotein I.
Circulation. 98: 1108-1115, 1998.
22. J. George, M. Pantaik, E. Bakshi, Y. Levy. A. Ben David, A. Ahmed, JB Peter, Y. Shoenfeld.
Seropositivity for Hantavirus in Isreali patients with end stage renal failure.
Viral Immunology. 11: 103-108, 1998.
23. J. George, B. Gilburd, M. Hojnik, Y. Levy, P. Langevitz, E. Matsuura, T. Koike, Y. Shoenfeld.
Target recognition of 2-glycoprotein I (2GPI)-dependent anticardiolipin antibodies: Evidence for involvement of the IV domain of 2GPI in antibody binding.
The Journal of Immunology 32: 116-125, 1998.
24. J. George, B. Gilburd, P Langevitz, Y. Levy, D. Harats, Y. Shoenfeld.
2-glycoprotein I containing immune complexes: association with thrombocytopenia and lipoprotein (a) levels.
Lupus. 8: 116-120, 1999.
25. J. George, Y. Shoenfeld, A. Afek, B. Gilburd, P. Keren, A. Shaish, Y. Kopolovic, D. Harats.
Enhanced fatty streak formation C57BL/6J mice by immunization with heat shock
protein 65.
Arterioscler Thromb Vasc Biol. 19: 505-510, 1999.
26. A. Afek, J. George, Y. Shoenfeld, B. Gilburd, Y. Levy, P. Keren, A. Shaish, D. Harats.
Enhanced Atherosclerosis in ApoE deficient mice by immunization with 2-glycoprotein I
Pathobiology. 67: 19-25, 1999.
27. J. George, D. Harats, B. Gilburd, Y. Levy, P. Langevitz, Y. Shoenfeld.
Atherosclerosis related markers in systemic lupus erythematosus patients: the role of humoral immunity in enhanced atherogenesis.
Lupus. 8: 220-226, 1999.
28. J. George, D. Harats, B. Gilburd, A. Afek, Y. Levy, J. Schneiderman, I. Barshack, J. Kopolovic, Y. Shoenfeld.
Immunolocalization of 2-glycoprotein I to human atherosclerotic plaques: potential implications for lesion formation.
Circulation. 99; 2227-2230, 1999.
29. A Shaish, J. George, B Gilburd, P Keren, H Levkovitz, D Harats.
Dietary -carotene and -tocopherol combination does not inhibit atherogenesis in an apoE deficient mouse model.
Arterioscler Thromb Vasc Biol. 19:1470-1475, 1999.
30. N. Zurgil, Y. Levy, K. Deutch, B. Gilburd, J. George, D. Harats, Y. Shoenfeld.
Reactivity of peripheral blood lymphocytes (PBL) to oxidized LDL: a novel system to estimate atherosclerosis employing the cell scan.
Clinical Cardiology. 22; 55-62, 1999.
31. Y. Levy, Y. Sherer, J. George, P. Langevitz, A. Ahmed, Y. Bar-dayan, F. Fabrizzi, J. Terryberry, JB Peter, Y. Shoenfeld.
Serologic and clinical response to treatment of systemic vasculitis associated autoimmune
disease with intravenous immunoglobulin.
Int Arch Allergy Immunol, 119; 231-238, 1999.
32. J. George, A. Aron, Y. Levy, A. Ben-David, M. Hojnik, Y. Renaudineau, A. Zonana-Nachach, P. Youinou, D. Harats, Y. Shoenfeld.
Anti-cardiolipin, anti-endothelial-cell and anti-malondialdehyde-LDL antibodies in uremic patients undergoing hemodialysis: relationship with vascular access thrombosis and thromboembolic events
Human Antibodies. 9; 125-131, 1999.
33. J. George, D. Harats, E. Bakshi, Y. Levy, Y. Adler, B. Gilburd, Y. Shoenfeld. Anti-oxidized-low density lipoprotein antibody determination as a predictor of restenosis following percutaneous transluminal coronary angioplasty.
Immunology letters. 68; 263-266, 1999.
34. J. George, Y. Shoenfeld, D. Harats.
The involvement of 2-glycoprotein I in human and murine atherosclerosis.
The Journal of Autoimmunity. 13; 57-60, 1999.
35. Y. Levy, J. George, BA Sela, P Langevitz, D Hatats, Y Shoenfeld.
Elevated homocysteine levels in patients with primary Raynaud’s syndrome.
J. Rheumatology. 26; 2383-2385. 1999.
36. A Afek, R Manor, I Goldberg, L Ziporen, J. George, Polak-Charcon, MC Amigo, Garcia-Torres, R Segal, Y Shoenfeld, J Kopolovic.
Increased endothelial cell expression of 31 integrin in Libman-Sacks endocarditis in the antiphospholipid syndrome.
Lupus. 8; 502-509, 1999.
37. Y. Levy, Y. Sherer, A. Ahmed, P Langevitz, J. George, F. Fabrizzi, J. Terryberry, M. Lorber, JB. Peter, Shoenfeld Y.
A study of 20 SLE patients with intravenous immunoglobulin-clinical and serologic response.
Lupus 8; 705-712, 1999.
38. A. Afek, J. George, B. Gilburd..D. Harats, Y. Shoenfeld.
Immunization with heat shock protein 65 enhances early atherosclerosis in low-density lipoprotein receptor deficient mice.
J. Autoimmunity. 14; 115-121, 2000.
39. Levy Y. Y. Sherer, .J. George, J. Rovensky, J. Lukac, L. Rauova, P Porprac, P. Langevitz, F. Fabbrizzi, Y. Shoenfeld
Intravenous gammaglobulin treatment of patients with lupus nephritis
Semin. Arthritis Rheum. 29: 321-327, 2000.
40. P. Keren, J. George, A. Shaish, H. Levkovitz, Z. Janakovic, A. Afek, I. Goldberg, J. Kopolovic, G. Keren, D. Harats.
The effect of combined hyperglycemia and hyperlipidemia on atherosclerosis in LDL-receptor
deficient mice: establishment of a combined model and association with heat shock protein 65 immunity.
Diabetes. 49; 1064-1069. 2000.
41. J. George, A. Ahmed, M. Pantaik, Y. Adler, Y. Levy, D. Harats, B. Gilburd, J. Terryberry, GQ Shen, A. Sagie, I. Herz, P. Snow, J Brandt, J Peter, Y. Shoenfeld.
The prediction of coronary atherosclerosis employing artificial neural networks.
Clinical Cardiology 23; 453-456, 2000.
42. D. Harats, A. Shaish, J. George, M. Mulkins, H. Kurihara, H. Levkovitz, E. Sigal.
Overexpression of the 12/15 lipoxygenase in vascular endothelium accelerates earkt atherosclerosis in LDL-receptor deficient mice.
Arterioscler Thromb Vasc Biol 20; 2100-2105, 2000.
43. Y. Adler, J. George, Y. Shoenfeld, N. Fink, I. Herz, A. Mager, A. Assali, D. Harats, A. Sagie.
Association between mitral annulus calcification and anti-2-glycoprotein antibody I levels.
The Journal of Non Invasive Cardiol. 3; 111-115, 1999.
44. S. Greenberg, A. Finkelstein, J. Gurevich, E. Brazowski, F. Rosenfeld, I. Shapira,
J. George, S. Laniado, G. Keren.
The effect of Agmatine on ischemic and non ischemic isolated rat heart
J Cardiovasc Pharmacol Therapeut. 4; 151-158, 1999.
45. J. George, Y. Shoenfeld, B.Gilburd, A. Afek, A Shaish, D. Harats.
Requisite role for IL-4 in the enhancement of fatty streaks by immunization with heat shock protein 65.
Circulation Research. 86; 1203-1210, 2000.
46. J. George, M. Mulkins, S. Casey, R. Schatzman, E. Sigal, D. Harats.
The effects of n-6 polyunsaturated fatty acid supplementation on the lipid composition and atherogenesis in mouse models of atherosclerosis.
Atherosclerosis. 150; 285-293, 2000.
47. J. George, D. Harats, B. Gilburd, A. Afek, Y. Shoenfeld.
Adoptive transfer of β2-glycoprotein I reactive lymphocytes promotes early atherosclerosis in LDL-receptor deficient mice.
Circulation. 102; 1822-1827, 2000.
48. J. George, M. Mulkins, A. Shaish, S. Casey, R. Schatzman, E. Sigal, D. Harats
Interleukin (IL)-4 Deficiency does not Influence Fatty Streak Formation in C57BL/6 Mice.
Atherosclerosis. 153; 403-411, 2000.
49. J. George, PL Meroni, B. Gilburd, Y. Adler, E. Raschi, D. Harats, Y. Shoenfeld
Anti-endothelial cell antibodies in patients with coronary atherosclerosis.
Immunol Lett. 73; 23-27, 2000.
50. S. Greenberg, G. Chernin, I. Shapira, J. George, Y. Wollman, S. Laniado G. Keren.
Captopril and L-Arginine have synergistic cardioprotective effect in ischemic reperfusion injury in the rat isolated heart
J Cardiovasc Pharmacol Therapeut. 5; 281-290, 2000.
51. Y. Shoenfeld, D. Harats, J. George.
Heat-shock protein 60/65, β2-glycoprotein I and oxidized LDL as players in murine Atherosclerosis.
J Autoimmunity. 15; 199-202, 2000.
52. J. George, A. Afek, B. Gilburd, Y. Shoenfeld, D.Harats.
Cellular and humoral immune responses to heat shock protein 65 promote early atherosclerosis in LDL-receptor deficient mice.
J Am Coll Cardiol. 38; 900-905, 2001
53. S. Greenberg, J. George, Y. Wollman, I. Shapira, S. Laniado, G. Keren.
The effect of agmatine administration on ischemic-reperfused isolated rat heart.
J Cardiovasc Pharmacol Therapeut. 6, 37-45, 2001.
54. P. Keren, J. George, A. G. Keren, D. Harats
Non-obese diabetic (NOD) mice are resistant to high fat diet induced atherosclerosis but exhibit an increased cellular immune response to glycated-LDL.
Atherosclerosis. 157; 285-292, 2001.
55. Y. Sherer, A. Tenenbaum, S. Praprotnik, J. Shemesh, M. Blank, E. Fisman, D. Harats, J. George, Y. Levy, J. Peter, M. Motro, Y. Shoenfeld.
Coronary artery disease but not coronary calcification is associated with elevated levels of cardiolipin, beta2 glycoprotein-I and oxidized LDL antibodies.
Cardiology 95; 20-24, 2001
56. J. George, I. Barshack, E. Malka, I. Goldberg, P. Keren, S. Laniado, G. Keren.
The effect of intravenous gammaglobulin on the progression of experimental autoimmune myocarditis in the rat.
Experimental & Molecular Pathology. 71; 55-62, 2001
57. A. Afek, G. Keren, D. Harats, J. George.
Whole body hyperthermia accelerates atherosclerosis in LDL receptor deficient mice.
Experimental & Molecular Pathology. 71; 63-72, 2001.
58. J. George, A. Afek, A. Shaish, H. Levkovitz, E. Sigal, D. Harats.
12/15 lipoxygenase gene disruption attenuates atherogenesis in LDL-receptor deficient mice:
Circulation. 104; 1646-1650, 2001.
59. G. Keren, S. Pri-chen, P. Keren, I. Barshack, I. Goldberg, J. George.
The effect of intravenous gammaglobulins on intimal thickening in a mouse model of arterial injury.
Atherosclerosis. 159; 77-83, 2001.
60. J. George, S. Greenberg, I. Barshack, S. Pri-Chen, M. Singh, G. Keren.
Immunization against heat shock protein 70 accelerates neointimal thickening in the rat carotid injury model.
J Am Coll Cardiol. 38; 1564-1569, 2001
61. Harats D, Yacov N, Gilburd B, Shoenfeld Y, George J.
Oral tolerance with heat shock protein 65 attenuates Mycobacterium tuberculosis-induced and high-fat-diet-driven atherosclerotic lesions. J Am Coll Cardiol. 2; 40:1333-8, 2002.
62. J. George, A. Afek, Keren P, Herz I, Goldberg I, Haklai R, Kloog Y, Keren G.
Functional inhibition of Ras by S-trans,trans-farnesyl thiosalicylic acid attenuates atherosclerosis in apolipoprotein E knockout mice. Circulation. 21; 105: 2416-22, 2002.
63. J. George, S. Biner, P. Keren, I. Barshack, I. Goldberg , J. Sherez, A. Levitzki,
G. Keren, A. Roth.
The Tyrphostin AG-556 Reduces Myocardial Infarct Size and Improves Cardiac Performance in the Rat.
Experimental & Molecular Pathology 74; 314-318, 2003.
64. M. Berger, E. Rubinraut, I. Barshack, A. Roth, G. Keren, J. George
Zinc reduces intimal hyperplasia in the rat carotid injury model.
Atherosclerosis. 175: 229-34, 2004.
65. J. George, A. Adler, Iris Barshack, G. Keren, A. Roth.
Suppression of myosin-induced and adoptively transferred myocarditis by prior treatment with complete Freund’s adjuvant.
Cardiovasc. Pathol. 13: 221-4, 2004.
66. J. George, I. Barshack, I. Goldberg, P. Keren, A. Gazit, A. Levitzki, G. Keren, A. Roth
The Effect of Early and Late Treatment with the Tyrphostin AG-556 on the Progression of Experimental Autoimmune Myocarditis.
Exp. Mol. Pathol. 76: 234-41, 2004.
67. Y. Michowitz, E. Goldstein, A. Afek, S. Abashidze, G. Keren, J. George
The involvement of Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) in atherosclerosis.
J Am Coll Cardiol 45:1018-24, 2005.
68. R. Rosso, A. Roth, I. Herz, H. Miller, G. Keren, J. George.
Serum levels of interleukin-18 in patients with stable and unstable angina pectoris.
Int J Cardiol 2015 44; 6: 435-9
69. J. George, I. Kitzis, D Zandorf, M. Golovner, S Laniado, A Roth. Nitrate withdrawal in clinically and hemodynamically stable patients with coronary artery disease.
Chest 124: 1652-7, 2003.
70. I. Barshack, P. Keren, I. Goldberg, J. Kopolovic, G. Keren, J. George.
Relation of preexisting anti-beta2GPI antibodies to infarct size in a rat model.
Cardiovasc Pathol. 12:195-201, 2003.
71. J. George, S.Greenberg, I. Barshack , I. Goldberg,G. Keren, A. Roth
Immunity to heat shock protein 65–an additional determinant in intimal thickening.
Immunity to heat shock protein 65–an additional determinant in intimal thickening. Atherosclerosis. 168: 33-8, 2003.
72. George J, Herz I, Goldstein E, Abashidze S, Deutch V, Finkelstein A, Michowitz Y, Miller H, Keren G.
Number and adhesive properties of circulating endothelial progenitor cells in patients with in-stent restenosis. Arterioscler Thromb Vasc Biol. 23: e57-60, 2003.
73. J. George, S. Ben Shmuel, I. Herz, S. Izraelov, V. Deutch, G. Keren, H. Miller
L-Arginine attenuates lymphocyte activation and anti-oxidized LDL antibody levels in unstable angina patients undergoing percutaneous coronary interventions.
Atherosclerosis. 174: 323-7, 2004.
74. J.George, J. Sack , I Barshack, P. Keren , I Goldberg, R. Haklai, G. Elad-Sfadia, Y. Kloog, Keren G.
Inhibition of Intimal Thickening in the Rat Carotid Artery Injury Model by a Nontoxic Ras Inhibitor. Arterioscler Thromb Vasc Biol. 24:363-8, 2004.
75. J. George, N. Yacov, E Breitbart, A. Shaish, B. Gilburd, Y. Shoenfeld, D. Harats. Suppression of Early Atherosclerosis in LDL-Receptor Deficient Mice by Oral Tolerance with β2-Glycoprotein I.
Cardiovascular Research. 62: 603-9, 2004.
76. J. George, E. Goldstein, V. Deutch, S. Abashidze, A. Finkelstein, I. Herz, G. Keren.
Circulating endothelial progenitor cells in patients with unstable angina: Association with systemic inflammation.
Eur Heart J. 25: 1003-8, 2004.
77. A. Afek, D. Harats, G. Keren, J. George
Evidence for the involvement of T cell costimulation through the B-7/CD28 pathway in atherosclerotic plaques from apolipoprotein E knockout mice
Exp Mol Pathol. 76: 219-23, 2004.
78. A. Afek, N. Zurgil,Y. Bar-Dayan,S. Polak-Charcon, I.Goldberg, M. Deutsch, J. Kopolovic,G. Keren, D. Harats, J. George.
Overexpression of 15-Lipoxygenase in the Vascular Endothelium is Associated with Increased Thymic Apoptosis in LDL Receptor-Deficient Mice.
Pathobiology. 71: 261-6, 2004.
79. A. Finkelstein, Y. Michowitz, S. Abashidze, H. Miller, G. Keren, J. George.
Temporal association between circulating proteolytic, inflammatory and neurohormonal markers in patients with coronary ectasia.
Atherosclerosis- 179:353-9, 2005.
80. A. Afek, D. Harats, G. Keren, J. George.
A functional role for inducible costimulator (ICOS) in atherosclerosis
Atherosclerosis 183: 57-63, 2005.
81. A. Adler, A. Roth, I. Herz, D. Wexler, G. Keren, J. George.
Functional T-lymphocyte dichotomy in the peripheral blood of patients with unstable angina
Int J Interven Cardiol 7: 146-51, 2005.
82. A. Finkelstein, S. Izraelov, A. Roth, S. Ben-Shmuel, G. Keren, H. Miller, J. George.
Eptifibatide does not influence lymphocyte activation and CRP levels in patients with undergoing coronary angioplasty.
Int J Interven Cardiol 6; 107-109, 2004
83. J. George, D. Wexler, T. Barak, D. Sheps, G. Keren.
Usefulness of anti-oxidized LDL antibody determination in assessment of clinical control in patients with congestive heart failure
Eur J Heart Failure 8: 58-62, 2006.
84. Y. Michowitz, A. Blatt, A. Frimmerman, A. Finkelstein, R. Massachi, I. Herz, R. Krakover, H. Miller, G. Keren, J. George
Stent thrombosis in patients treated with thienopyridines: Clinical description of 10 cases
Int J Interv Cardiol. 6; 160-164, 2004.
85. J. George, I. Barshack, P. Keren, S. Pri-chen, I. Goldberg, A. Levitzki, G. Keren.
The Effect of Tyrphostin AG-556 on Intimal Thickening in a Mouse Model of Arterial Injury.
Exp Mol Pathol 78: 233-8, 2005.
86. J. George, S. Patal, D. Wexler, S. Abashidze, T. Barak, D. Sheps, G. Keren.
Circulating matrix metalloproteinase-2 (MMP-2) but not MMP-3, -9 or TIMP-1 predict outcome in patients with congestive heart failure.
Am Heart J 150:484-7, 2005.
87. J. George, S. Patal, D. Wexler, S. Abashidze, D. Sheps, G. Keren.
Circulating erythropoietin and outcome in patients with congestive heart failure: comparison with neurohormonal and inflammatory markers.
Archives of Internal Medicine. 165: 1304-9, 2005.
88. J. George, A. Afek, S. Abashidze, H. Shmilovich, V. Deutsch, J. Kopolovich, H. Miller, G. Keren.
Transfer of endothelial progenitor and bone-marrow cells influences atherosclerotic plaque size and composition in apolipoprotein E knockout mice.
Arterioscler Thromb Vasc Biol 25: 2636-41, 2005.
89. J. George, E. Goldstein, A. Abashidze, D. Wexler, S. Hamed, H. Shmilovich, V. Deutsch, H. Miller, G. Keren, A. Roth.
Erythropoietin promotes endothelial progenitor cell proliferative and adhesive properties in a PI3-kinase-dependent manner.
Cardiovasc Res. 68: 299-306, 2005.
90. L. Werner, V. Deutsch, I. Barshack, H. Miller, G. Keren, J. George
Transfer of endothelial progenitor cells improves myocardial performance in rats with dilated cardiomyopathy following experimental myocarditis
J Moll Cell Cardiol 39; 691-697, 2005.
91. J. George, H. Shmilovich, S. Abashidze, V. Deutsch, M. Pick, H. Miller, G. Keren.
Comparative analysis of methods for assessment of circulating endothelial progenitor cells.
Tissue Engineering 12; 331-5, 2006.
IF 4.7 BIOTECHNOLOGY & APPLIED MICROBIOLOGY 13/144
92. J George, S Patal, D Wexler, Y Sharabi, E Peleg, S Abashidze, H Shmilovich, Y Kamari, E Grossman, D Sheps, G Keren
Circulating adiponectin levels in patients with congestive heart failure.
Heart –92:1420-4, 2006.
93. M. Moraru, A Roth, G Keren, J George
Cellular autoimmunity to cardiac myosin in patients with recent myocardial infarction.
Int J Cardiol. 107: 61-66, 2006.
IF-3.1 Cardiac and Cardiovascular system 24/79
94. I. Herz I, R Rosso, G. Keren, J George.
Anti –HSP70 antibody levels in patients with unstable angina.
Acute Car Care– 8: 46-50, 2006.
95. S. Hamed I Barshack, G Luboshits, D Wexler, J Sherez, V Deutsch, H Miller, G Keren,
J George
Erythropoietin improves myocardial performance in doxorubicin-induced cardiomyopathy: a potential role for endothelial progenitor cells.
Eur Heart J. 27:1876-83, 2006.
96. A. Glick, Y. Michowitz, G. Keren, J. George.
Short-term assessment of neurohormonal and inflammatory markers as a predictor of outcome in heart failure patients with cardiac resynchronization therapy.
IMAJ 8: 391-395, 2006.
97. J. Ablin, V. Shatz, D. Caspi, O. Elkayam, G. Keren, J. George.
Effect of anti TNFα treatment on Circulating Endothelial Progenitor Cells (EPCs) and on endothelial function in rheumatoid arthritis.
Life Sciences. 17;79:2364-9, 2006.
98. A. Mor, G. Luboshits, G. Keren, J. George
Altered numbers and functional status of naturally occurring CD4+CD25+ regulatory T cells in patients with acute coronary syndromes
Eur Heart J. 27: 2530-7, 2006.
99. H. Shmilovich, A. Danon, O. Binah, G. Chen, D, Wexler, D. Sheps, G. Keren, J. George
Autoantibodies to Troponin I in patients with ischemic and idiopathic dilated cardiomyopathy
Int J Cardiol. 117: 198-203, 2007
100. H. Shmilovich, V. Deutsch, A. Roth, H. Miller, G. Keren, J. George.
Circulating endothelial progenitor cells in patients with cardiac syndrome X.
Heart. 93(9):1071-6, 2007
101. A. Mor, D. Planer, G. Luboshits, A. Afek, G. Keren, J. George.
The role of naturally occurring CD4+CD25+ regulatory T cells in experimental atherosclerosis.
Arterioscler Thromb Vasc Biol. 2007 Apr;27(4):893-900
102. Y. Michowitz, E. Goldstein, D. Wexler, D. Sheps, G. Keren, J. George
Circulating endothelial progenitor cells and clinical outcome in patients with congestive heart failure
Heart. 2007 Sep;93(9):1046-50.
103. Schwartzenberg S, Deutsch V, Maysel-Auslender S, Kissil S, Keren G, George J
Circulating apoptotic progenitor cells: a novel biomarker in patients with acute coronary syndromes.
Arterioscler Thromb Vasc Biol. 2007 May;27(5):e27-31
104. A. Mor, G. Keren, Y. Kloog, J. George
N-Ras or K-Ras inhibition increases the number and enhances the function of Foxp3 regulatory T cells.
Eur J Immunol 2008 Jun;38(6):1493-502.
105. Mausner-Fainberg K, Luboshits G, Mor A, Maysel-Auslender S, Rubinstein A, Keren G, George J.
The effect of HMG-CoA reductase inhibitors on naturally occurring CD4+CD25+ T cells.
Atherosclerosis. 2008 Apr;197(2):829-39.
106. Finkelstein A, Bazan S, Halkin A, Herz I, George J, Miller HI, Keren G, Banai S.
Treatment of post-catheterization femoral artery pseudo-aneurysm with para-aneurysmal saline injection.
Am J Cardiol. 2008 May 15;101(10):1418-22.
IF-3.1 Cardiac and Cardiovascular system 14/79
107. Michowitz Y, Arbel Y, Wexler D, Sheps D, Rogowski O, Shapira I, Berliner S, Keren G, George J, Roth A.
Predictive value of high sensitivity CRP in patients with diastolic heart failure.
Int J Cardiol. 2008 Apr 25;125(3):347-51.
108. A. Barsheshet, I. Barshack, P. Keren, G. Keren, J. George
Whole-body hyperthermia attenuates experimental autoimmune myocarditis in the rat.
Cardiovasc Pathol. 2008 Nov-Dec;17(6):375-81
109. D. Geft, S. Schwartzenberg, O. Rogovski, Finkelstein A, J. Ablin, S. Maysel Auslender, D. Wexler, G. Keren, J. George.
Circulating apoptotic progenitor cells in patients with congestive heart failure.
PLoS ONE. 18; 3(9):e3238.
110. Ben Shoshan J, S. Maysel-Auslander, A. Mor, G. Keren, J. George
Hypoxia controls CD4(+)CD25(+) regulatory T-cell homeostasis via hypoxia-inducible factor-1alpha.
Eur J Immunol. 38: 2412-2418, 2008.
111. J. Ben Shoshan, S. Schwartz, G. Luboshits, S. Maysel Auslender, A. Barzelay, S. Polack Charcon, I. Barshack, A. Barak, H. Levkovitch Verbin, G. Keren, J. George.
Constitutive Expression of HIF-1{alpha} and HIF-2{alpha} in Bone Marrow Stromal Cells Differentially Promote their Pro-angiogenic Properties.
Stem Cells. 2008 Oct;26(10):2634-43.
112. Schwartz S, George J, Ben-Shoshan J, Luboshits G, Avni I, Levkovitch-Verbin H, Ziv H, Rosner M, Barak A.
Drug modification of angiogenesis in a rat cornea model.
Invest Ophthalmol Vis Sci. 2008 Jan;49(1):250-4.
113. Ablin JN, Goldstein Z, Aloush V, Matz H, Elkayam O, Caspi D, Swartzenberg S, George J, Wohl Y. Normal levels and function of endothelial progenitor cells in patients with psoriatic arthritis.
Rheumatol Int. 2009 Jan;29(3):257-62.
114. S. Schwartzenberg, A. Mor, G. Luboshits, D. Planner, V. Deutsch, G. Keren, J. George.
Association between circulating early endothelial progenitors and CD4+CD25+ regulatory T cells: a possible cross-talk between immunity and angiogenesis ?
Am J Immunol. 2010; 4: 334-10
115. J. Ben Shoshan, S. Maysel-Auslender, Galia Luboshits, I. Barshack, S. Polak-Charcon, E. Tzahor, G. Keren, J. George.
Hypoxia Inducible Factor 1α (HIF-1α) and HIF-2α Additively Promote Endothelial Vasculogenic Properties.
J Vasc Res. 2008 Dec 11;46(4):299-310.
116. A Adler, A Afek, Y Levy, G Keren, J George.
Antiphospholipid antibodies from a patient with primary antiphospholipid syndrome enhance experimental atherosclerosis.
Nature Cardiovasc Med. 2009 Mar;6(3):215-8.
117. Y Michowitz, S Kisil, H Guzner-Gur, D Wexler, D Sheps, G Keren, J George
Usefulness of serum myeloperoxidase in prediction of mortality in patients with severe heart failure.
IMAJ. 2008 Dec;10(12):884-8.
118. Pando R, Barshack I, Raz A, Maysel Auslander S, Kloog Y, Keren G, George J.
The Ras Antagonist FTS ameliorates experimental autoimmune myocarditis
Cardiovasc Pathol. 2009; 18:176-88.
IF-1.92 Cardiac and Cardiovascular system 42/79
119. A.Afek, E. Kogan, S. Maysel Auslender, A. Mor, G. Keren. J. George
Clopidogrel attenuates atheroma formation and induces a stable plaque phenotype in apolipoprotein E knockout mice.
Microvasc Res. 2009 May;77(3):364-9.
120. Ben-Shoshan J, Afek A, Maysel-Auslender S, Barzelay A, Rubinstein A, Keren G, George J.
HIF-1alpha overexpression and experimental murine atherosclerosis.
Arterioscler Thromb Vasc Biol. 2009 May;29(5):665-70.
121. Shmilovich H, Ben-Shoshan J, Tal R, Afek A, Barshack I, Maysel-Auslander S, Harats D, Keren G, George J.
B-type Natriuretic Peptide Enhances Vasculogenesis by Promoting Number and Functional Properties of Early Endothelial Progenitor Cells.
Tissue Eng Part A. 2009: 15 1471-9
122. Pando R, Cheporko Y, Mayzel S, Haklai R, Keren G, George J, Kloog Y, Sagie A, Hochauser E.
Ras inhibition attenuates myocardial ischemia-reperfusion injury.
Biochem Pharmacol. 2009 May 15;77(10):1593-601
123. Mor A, Kloog Y, Keren G, George J.
Ras inhibition attenuates diabetes in the NOD mouse model.
Eur J Pharmacol. 2009 Aug 15;616(1-3):301-5.
124. Charach G, George J, Wexler D, Sheps D, Keren G, Rubinstein A.
Antibodies to oxidized LDL as predictors of morbidity and mortality in patients with chronic heart failure.
J. Card Failure. J Card Fail. 2009 Nov;15(9):770-4.
125. Barzelay A, Ben Shoshan J, Entin Meer M, Maysel Auslander S, Afek A, Barshack I, Keren G, George J.
A potential role of islet-1 in post natal angiogenesis and vasculogenesis.
Thromb Haemostasis. 2010:103: 188-197
125. Charach G, George J, Roth A, Rogowski O, Sheps D, Wexler D, Weintraub M, Groscopf I, Keren G, Rubinstein A. Baseline LDL cholesterol levels and outcome in patients with congestive heart failure. Am J Cardiol. 2010; 105: 100-104.
126. Mor A, Aizman E, George J, Kloog Y. Mor A, Aizman E, George J, Kloog Y. Ras inhibition induces insulin sensitivity and glucose uptake. Plos One 2011;6(6):e21712. IF 4/4 12/84 General Biology 127. Finkelstein A, Schwartzenberg S, Bar L, Levy Y, Halkin A, Herz I, Bazan S, Massachi R, Banal S, Keren G, George J. Comparative efficacy analysis of an aspiration device before primary angioplasty in patients with acute myocardial infarction: a single-center experience. Isr Med Assoc J. 2010 Nov;12(11):692-6.
128. Schwartzenberg S, Afek A, Charach G, Rubinstein A, Ben-Shoshan Y, Kissil S, Maisel-Auslender S, Keren G, George J. Comparative analysis of the predictive power of different endothelial progenitor cell phenotypes on cardiovascular outcome. World J Cardiol. 2010 Sep 26;2(9):299-304
129. Shimoni S, Zilberman L, Edri O, Bar I, Goland S, Gendelman G, Swissa M, Livshitz S, Paz O, Ayzenberg O, George J. Thoracic aortic atherosclerosis in patients with aortic regurgitation.
Atherosclerosis. 2011 Sep;218(1):107-9.
130. Charach G, Rubalsky O, Charach L, Rabinovich A, Argov O, Rogowski O, George J.
Internal thoracic impedance – a useful method for expedient detection and convenient monitoring of pleural effusion.
PLoS One. 2015 Apr 28;10(4):e0122576.
131. Sharir R, Semo J, Shimoni S, Ben-Mordechai T, Landa-Rouben N, Maysel-Auslender S, Shaish A, Entin-Meer M, Keren G, George J.
Experimental myocardial infarction induces altered regulatory T cell hemostasis, and adoptive transfer attenuates subsequent remodeling.
PLoS One. 2014 Dec 1;9(12):e113653.. eCollection 2014.
132. Volodarsky I, Shimoni S, George J.
The current status of transcutaneous aortic valve implantation.
Expert Rev Cardiovasc Ther. 2014 Oct;12(10):1205-18..
133. Sharir R, Semo J, Shaish A, Landa-Rouben N, Entin-Meer M, Keren G, George J.
Regulatory T cells influence blood flow recovery in experimental hindlimb ischaemia in an IL-10-dependent manner.
Cardiovasc Res. 2014 Sep 1;103(4):585-96. doi: 10.1093/cvr/cvu159. Epub 2014 Jun 25.
134. George J, Matucci-Cerinic M, Bar I, Shimoni S.
Circulating autoantibodies to endothelial progenitor cells: binding characteristics and association with risk factors for atherosclerosis.
PLoS One. 2014 Jun 19;9(6):e97836.. eCollection 2014.
135. Shimoni S, Bar I, Zilberman L, George J.
Autoantibodies to oxidized low-density lipoprotein in patients with aortic regurgitation: association with aortic diameter size.
Cardiology. 2014;128(1):54-61..
136. Schwartzenberg S, Meledin V, Zilberman L, Goland S, George J, Shimoni S.
Low circulating monocyte count is associated with severe aortic valve stenosis.
Isr Med Assoc J. 2013 Sep;15(9):500-4.
137. Semo J, Sharir R, Afek A, Avivi C, Barshack I, Maysel-Auslender S, Krelin Y, Kain D, Entin-Meer M, Keren G, George J.
The 106b∼25 microRNA cluster is essential for neovascularization after hindlimb ischaemia in mice.
Eur Heart J. 2014 Dec 1;35(45):3212-23..
138. Shimoni S, Bar I, Zilberman L, Goland S, Edri O, Gandelman G, Afek A, Shamiss A,
George J.
Circulating progenitor and apoptotic progenitor cells in patients with aortic regurgitation.
Circ J. 2013;77(3):764-71..
139. Shimoni S, George J.
Circulating endothelial cells, plaque rupture and acute coronary syndromes.
Expert Rev Cardiovasc Ther. 2012 Aug;10(8):985-7.
140. George J, Schwartzenberg S, Medvedovsky D, Jonas M, Charach G, Afek A, Shamiss A.
Regulatory T cells and IL-10 levels are reduced in patients with vulnerable coronary plaques.
Atherosclerosis. 2012 Jun;222(2):519-23.
141. Schwartzenberg S, Benderly M, Malnick S, George J, Goland S.
The “obesity paradox”: does it persist among Israeli patients with decompensated heart failure? A subanalysis of the Heart Failure Survey in Israel (HFSIS).
J Card Fail. 2012 Jan;18(1):62-7..
142. Shimoni S, Bar I, Meledin V, Gandelman G, George J.
Circulating regulatory T cells in patients with aortic valve stenosis: Association with disease progression and aortic valve intervention.
Int J Cardiol. 2016 Sep 1;218:181-7..
143. Shimoni S, Meledin V, Bar I, Fabricant J, Gandelman G, George J.
Circulating CD14(+) monocytes in patients with aortic stenosis.
J Geriatr Cardiol. 2016 Jan;13(1):81-7.
144. Shimoni S, Bar I, Meledin V, Derazne E, Gandelman G, George J.
Circulating Endothelial Progenitor Cells and Clinical Outcome in Patients with Aortic Stenosis.
PLoS One. 2016 Feb 25;11(2):e0148766.
145. Goland S, Perelman S, Asalih N, Shimoni S, Walfish O, Hallak M, Hagay Z, George J, Shotan A, Blondheim DS.
Shortness of Breath During Pregnancy: Could a Cardiac Factor Be Involved?
Clin Cardiol. 2015 Oct;38(10):598-603..
146. Charach G, Michowitz Y, Rogowski O, Charach L, Argov O, George J, Grosskopf I.
Usefulness of Antibodies to Oxidized Low-Density Lipoproteins as Predictors of Morbidity and Prognosis in Heart Failure Patients Aged ≥65 Years.
Am J Cardiol. 2015 Nov 1;116(9):1379-84.
147. Atrial fibrillation and CHADS2 score as mortality predictors in young versus elderly patients undergoing coronary angiography. Teodorovich N, Swissa MS, Kogan Y, Gandelman G, Jonas M, George J, Swissa M. J Geriatr Cardiol. 2017 Sep;14(9):582-586.
148. Angiogenic Imbalance and Residual Myocardial Injury in Recovered Peripartum Cardiomyopathy Patients. Goland S, Weinstein JM, Zalik A, Kuperstein R, Zilberman L, Shimoni S, Arad M, Ben Gal T, George J.Circ Heart Fail. 2016 Nov;9(11). 149. Circulating regulatory T cells in patients with aortic valve stenosis: Association with disease progression and aortic valve intervention. Shimoni S, Bar I, Meledin V, Gandelman G, George J. Int J Cardiol. 2016 Sep 1;218:181-187 150. Elevated Levels of Eotaxin-2 in Serum of Fibromyalgia Patients. Furer V, Hazan E, Mor A, Segal M, Katav A, Aloush V, Elkayam O, George J, Ablin JN. Pain Res Manag. 2018 May 13;2018:7257681. 151. Goland S, Fugenfirov I, Volodarsky I, Aronson H, Zilberman L, Shimoni S, George J. Left Ventricular Reverse Remodeling in Recent Onset Idiopathic Dilated Cardiomyopathy Using Contemporary Echo Techniques. Isr Med Assoc J. 2018 Dec;20(12):749-753

B.2 Case reports

1. Y. Levy Y, J. George, Y. Shoenfeld.
Severe blastocystis hominis in an elderly man.
Journal of Infection 33; 57-59, 1996.
2. Y. Levy, M. Solgov, J. George, Y. Shoenfeld.
“BCGitis” – sepsis following BCG treatment for Bladder carcinoma.
Harefuah12: 541-543, 1996.
3. J. George, B. Avidan, Y. Shoenfeld.
Iatrogenic damage.
Harefuah 130: 53-56, 1996.
4. Y. Levy, J. George, Y. Eli, Y. Shoenfeld.
Partial liposdystrophy and complement dysfunction.
Turk J Immunol 2: 43-45, 1996.
5. O. Shovman, J. George, Y. Shoenfeld.
Ischemic Hepatitis In a patient with congestive heart failure and hypotension.
Harefuah 132; 459-450, 1997
6. O. Shovman, J. George, Y. Shoenfeld.
Endocarditis in a patient with Q fever.
Harefuah. 133; 281-283.
7. Y. Levy, J. George, A. Livneh, A. Migdal, Y. Shoenfeld.
Subcutaneous T cell lymphoma in an elderly man not treated with cytotoxic agents.
Clinical Rheumatology. 16: 606-608, 1997.
8. O. Shovman, J George, Y Shoenfeld.
Primary subclavian vein thrombosis following strenous physical activity.
Harefuah 133: 610-612, 1997.
9. Y. Levy, J. George, F. Fabirzzi, P. Rotman, Y. Paz, Y. Shoenfeld.
Marked improvement of Churg Strauss vacultis with intravenous gammaglobulin.
South M Journal. 92; 412-414, 1999.

B.3. Review Articles

1. J. George, Y. Adler, J. Zhang, Y. Shoenfeld.
Apoptosis and its association with autoimmunity.
Clinical Rheumatology 14: 505-509, 1995.
2. J. George, Y. Adler, Y. Shoenfeld.
Apoptosis-programmed cell death, Autoimmune aspect.
Harefuah 129: 339-441, 1995.
3. J. George, Y. Shoenfeld.
Atherosclerosis as an immune disease.
Harefuah 129: 257-259, 1995
4. J. George, Y. Shoenfeld.
Hanta-virus, clinical syndromes.
Harefuah. 129; 421-423, 1995
5. M. Hojnik, J. George, L. Ziporen, Y. Shoenfeld.
Heart valve involvement (Libman-Sacks endocarditis) in the antiphopholipid syndrome.
Circulation. 93; 1579-1587, 1996.
6. J. George, D. Harats, B. Gilburd, Y. Shoenfeld.
Emerging cross-regulatory roles of immunity and autoimmunity in atherosclerosis.
Immunologic Research. 15; 315-322, 1996.
7. J. George, Y. Levy, Y. Shoenfeld.
Immune network and autoimmunity.
Internal Medicine 35: 3-9, 1996.
8. Y. Shoenfeld, J. George, JB. Peter.
Guillain-barre as an autoimmune disease.
Int Arch Allergy Immunol .109; 318-326, 1996.
9. J. George, Y. Shoenfeld.
The fourth international conference on SLE, highlights regarding pregnancy and antiphopholipid syndrome.
Early Preg. Biol Med 2: 53-69, 1996.
10. J. George, Y. Levy, Y. Shoenfeld.
Mixed connective tissue disease-33 years of uncertainty.
Harefuah. 130:99-104, 1996.
11. J. George, Y. Shoenfeld.
Fungi and autoimmune disease.
Harefuah. 136; 388-390, 1996.
12. J. George, Y. Levy Y, Y. Shoenfeld.
Smoking and immunity; an additional factor in the mosaic of autoimmunity.
Scandinavian Journal of Immunology. 45; 1-6, 1997.
13. J. George, B. Gilburd, Y. Shoenfeld.
The emerging concept of pathogenic natural autoantibodies.
Human Antibody Hybridomas. 18; 70-75, 1997.
14. J. George, Y. Levy, Y. Shoenfeld.
The idiotypic network- from animal models to clinical practice.
Japanese Journal of Rheumatology. 7: 75-82, 1997
15. J. George, Y. Levy, CGM. Kallenberg, Y. Shoenfeld.
Infections and Wegener’s granulomatosis; a cause and effect relationship?
Q J Med.; 90: 367-373, 1997.
16. J. George, Y. Shoeneld.
The antiphospholipid (Hughes) syndrome: a crossroads of autoimmunity and atherosclerosis.
Lupus 6: 559-560, 1997.
17. Y. Shoenfeld, J. George.
Induction of autoimmunity; a role for the idiotypic network
Annals of the NY Academy of Sciences 342-349, 1997.
18. D. Harats, J. George, Y. Levy, GRV Hughes, M. Khamashta, Y. Shoenfeld.
Atheroma: links with antiphospholipid antibodies, Hughes syndrome and lupus
QJM. 9; 57-59, 1999.
19. Y. Shoenfeld, D. Harats, J. George.
Atherosclerosis and the antiphospholipid syndrome: a link unravelled?
Lupus. 7 (Suppl 2): S140-143, 1998.
20. Y. Levy, J. George, E. Yona, Y. Shoenfeld.
Partial lipodystrophy, mesangiocapillary glomerulonephritis and complement dysregulation.
Immunologic Research 18: 55-60, 1998.
21. A Kollemeier, M. Kreditor, J. George, Y. Levy, Y. Shoenfeld.
Functional properties of anti-endothelial cell antibodies.
Clin Rev Allergy Immunol 16: 297-232,1998.
22. E. Bakshi, J. George, D. Harats
The role of oxidized LDL in atherosclerosis.
Harefuah 135: 459-463, 1998.
23. E. Bar Meir, J. George, Y. Shoenfeld.
Hyeprhomocysteinemia-a risk factor for vascular disease.
Harefuah 136: 129-133, 1999.
24. J. George, D. Harats, Y. Shoenfeld.
Inflammatory and immune aspects of atherosclerosis.
IMAJ 2: 112-116, 1999 .
25. J. George, Y. Shoenfeld
Accelerated atherosclerosis in the antiphospholipid syndrome: is there a role fore anti-β2 glycoprotein I antibodies?.
Rheuma21st (Internet) 1-4, 1999.
26. J. George, Y. Shoenfeld
The mosaic pathogenesis of autoimmune diseases: involvement of atherosclerosis.
Aspekte. 1999; 12/99
27. J. George, B. Gilburd, Y. Shoenfeld
Autoantibody spread as an explanation for the multiplicity of antibodies in autoimmune diseases.
The immunologist. 7/6 189-194, 1999.
28. J. George, A. Afek, B. Gilburd, D. Harats, Y. Shoenfeld.
Autoimmunity in atherosclerosis: Lessons from experimental models.
Lupus. 9; 223-227, 2000.
29. Y. Shoenfeld, Y. Sherer, J. George, D. Harats
Autoantibodies associated with atherosclerosis.
Ann Med 32 Suppl 1: 37-40, 2000.
30. Y. Shoenfeld, Y. Sherer, J. George, D. Harats
β2-glycoprotein I in human and murine atherosclerosis
IMAJ 3; 85-87, 2001.
31. P. Gordon, J. George, M. Khamashta, D. Harats, GRV Hughes, Y. Shoenfeld.
Autoimmunity and atherosclerosis.
Lupus 10; 249-252, 2001.
32. D. Harats, J. George
β2 glycoprotein I and atherosclerosis
Current Opinion in Lipidology. In press.
33. D. Harats, J. George
Antigen-tailored therapy based on the inflammatory theory of atherosclerosis. Expert Rev Vaccines. 3:605-11, 2006.
34. S. Schwartzenberg, J. Ben Shoshan, G. Keren, J. George
The role of erythropoietin in myocardial protection: potential mechanisms and applications.
Exp Rev Cardiovasc Ther 4: 41-50, 2006.
35., Keren G, George J
Erythropoietin as a protective agent in myocardial ischemia.
Harefuah. 2006 May;145(5):380-3, 396.
36. J. Ben Shoshan, G. Keren, J. George
Endothelial progenitor cells (EPCs)–new tools for diagnosis and therapy.
Harefuah. 2006 May;145(5):362-6, 397
37. J. Ben Shoshan, J. George
Endothelial progenitor cells as therapeutic vectors in cardiovascular disorders: from experimental models to human trials.
Pharmacol Ther. 2007 Jul;115(1):25-36.
38. J. George.
Erythropoietin and outcome prediction in patients with heart failure: the plot thickens…
Eur Heart J. 2008 Jun;29(12):1481-2
39. J. George
Mechanisms of Disease: The Emerging Role of Regulatory T cells in Atherosclerosis.
Nature Clincal Prac Cardiovasc Med. 2014

B4. CHAPTERS IN BOOKS

1. J. George, Y. Shoenfeld.
Anti-actin antibodies.
In: Autoantibodies. Eds. Peter J.B.& Shoenfeld Y. Elsevier, The Netherlands, 1998.
2. J. George, Y. Shoenfeld.
Natural autoantibodies.
In: Autoantibodies. Eds. Peter J.B.& Shoenfeld Y. Elsevier, The Netherlands, 1998.
3. M. Lorber, J. George, Y. Shoenfeld.
Hidden Autoantibodies.
In: Autoantibodies. Eds. Peter J.B.& Shoenfeld Y. Elsevier, The Netherlands, 1998.
4. J. George, M. Elkan, Y. Shoenfeld.
BCG.
Encyclopedia of Immunology. Eds. Ivan Roit, 1999.
5. J. George, Y. Shoenfeld
Autoimmunity and immune-mediated inflammation.
Cancer and Autoimmunity Eds Shoenfeld & Gershwin, Elsevier, 1-15; 2000.
6. J. George, Y. Shoenfeld
The smoking autoimmunity connection.
Cancer and Autoimmunity Eds Shoenfeld & Gershwin, Elsevier, 309-314; 2000.
7. T. Goldkorn, J. George, SN Lavrendtiadou, T. Ravid, A.Tsaba, Y. Shoenfeld, D. Harats.
Ceramide pathway and apoptosis in autoimmunity and atherosclerosis.
Atherosclerosis and autoimmunity Eds: Shoenfeld, Harats, Wick, Elsevier; 55-73, 2001.
8. Y. Shoenfeld, J. George, Y. Sherer, D. Harats.
Atherosclerosis: evidence for the role of autoimmunity.
Atherosclerosis and autoimmunity Eds: Shoenfeld, Harats, Wick, Elsevier; 139-144, 2001.
9. J. Ben Shoshan, J. George
Endothelial progenitors. In: Progress in Stem Cell Research.Nova Publishing
2015
10. Entin Meer M, J. George
Atherosclerosis, Foxp3 and regulatory T cells. Forkhead transcription factors and regulatory T cells. Elsevier 2010.

G. OTHER PUBLICATIONS

1. J. George, Y. Shoenfeld.
Infections idiotypes and SLE.
Lupus 4: 333-335, 1995 (editorial).
2. J. George, Y. Shoenfeld.
How does a viral infection trigger an autoimmune disease?
Viral Immunology 8: 189-190, 1995. (Viewpoint).
3. J. George, Y. Levy, Y. Shoenfeld.
Infections and autoimmunity-emerging clinical trials.
Turk J Immunol. 1; 1-13, 1996. (Editorial).
4. J. George, Y. Shoenfeld.
Cellular immune response in rheumatic Fever.
Harefuah. 131; 321-322, 1996. (Editorial).
5. J. George, Y. Levy, A. Afec, Y. Ron, Y. Shoenfeld.
Leukocytoclasic vasculitis after coronary bypass artery surgery.
British Journal of Dermatology. 135; 1015-1016, 1996 (letter to editor)
6. J. George, Y. Shoenfeld.
Natural autoantibodies. Immunology section.
a. Synthesis on-net (Internet, English), 1996.
b. Synthesis, (Hebrew), 1996
Patents
1. A composition for the prevention and/or treatment of atherosclerosis 1999
2. Methods employing and compositions containing plaque associated molecules for prevention and treatment of atherosclerosis 2001
3. Compositions containing beta 2-glycoprotein i for the prevention and/or treatment of vascular disease 2004
4. Enhancement of regulatory t cells’ activity using statins 2006
5. Treatment of myocarditis using fts 2008
6. Eotaxin-2 (ccl24) inhibitors in inflammatory, autoimmune, and cardiovascular disorders 2010
7. Treatment of post-angioplasty restenosis and atherosclerosis with Ras antagonists 2001
8. Oxidized lipids and uses thereof in the treatment of inflammatory diseases and disorders 2011